Meet QuantaKinome™
QuantaKinome™ is a targeted mass spectrometry-based phosphoproteomics technology. This is a highly specific and sensitive technique which selectively quantifies phosphorylated activation loops of protein kinases within complex human samples.
Discover the technology behind our kinome activity phosphoproteomics platforms.
Actionable translation in drug development through in-depth kinase activity profiling.
QuantaKinome™ deeply and directly quantifies the activity of more than one third of the known kinome in its native environment in a single run.
A groundbreaking, targeted MS-based technology for profiling the network activity of endogenous protein kinases in human samples.
QuantaKinome™ features |
Your Benefits |
|---|---|
| Endogenous kinase activity data | The most relevant information for compound development |
| Broadest coverage of pathways | Insight in all critical kinome pathway activities |
| Wide range of sample types | One single assay from compound discovery to the clinic |
| Ultra-sensitive | Detection of low-abundant kinases, in smallest possible samples |
| Ultra-precise quantification | Highly reproducible between samples, experiments, patients |
| Ultra-specific | Distinguishes even highly similar kinase isoforms |
| Multiplex kinetic measurements | Monitors pathway activity rewiring and resistance mechanisms over time |
| Customizable | Select your pathway of choice |
| Fit-for-purpose assay | Assay development for RUO and CLIA/FDA/EMA approved |
Tune your modelling in various samples & therapeutic areas
Compose your drug development with integrated feedback
You can apply QuantaKinome™ throughout development phases and between human models to provide you with actionable translation. Measure the same data regardless of where you are and compare data to truly understand human kinome activity.
Target
Discovery
Lead Optimization
Pre-Clinical Research
Clinical Research
Tune your PKI MOA game in 4 value-adding steps
4
Off-target activities known
Unforeseen side effects are cought by insight knowledge
3
Pathway engagement confirmed
Downstream pathway inhibition is essential
2
Target engagement confirmed
Endogenous kinase activities are key to successful compounds
1
Set the right assay time window (kinetics)
Conscious timepoints lead to correct drug effect conclusions
Tune your PKI MOA game in 4 value-adding steps
1
Setting the right assay time window
Set the right assay time window (kinetics)
2
Target engagement confirmed
Endogenous kinase activities are key to successful compounds
3
Pathway engagement confirmed
Downstream pathway inhibition is essential
4
Off-target activities known
Unforeseen side effects are cought by insight knowledge
