Identifying Clinical Biomarkers
By understanding Kinase Activity in drug development.
Getting in tune with next generation needs
Biomarkers are a vital part of developing new treatments for patients who suffer from cancer or other chronic diseases. Biomarkers are able to show the biological function or malfunction within an individual, which can be used to diagnose, monitor and predict disease progression.
Biomarkers are essential for a PKI candidates’ success in each phase of the PKI development pipeline. They are measured as either the direct or indirect target of a PKI. Biomarkers are able to show the biological function or malfunction within an individual, which can be used to diagnose, monitor and predict disease progression. To be a more direct read out for a PKI’s efficacy and toxicity, next generation actionable biomarkers should measure endogenous kinase activity since PKIs directly target this activity. In addition, a biomarker panel is more effective for molecular heterogenous diseases and allows better patient stratification.
Our advantages
Pepscopes’ quantitative, targeted mass spectrometry technology for biomarker and MOA analyses in a range of human cell samples. A solution to help you compose a melody that starts with the end in mind and provides integrated feedback.
Highly quantifiable in physiological relevant sample types
High kinome coverage to measure biomarker panels
High reproducibility and repeatability for monitoring the status of a disease
Developing tailored Biomarker Panels with Kinome Activity Profiling
Panel-based assays are an important tool in the development of precision medicine. Kinase activity profiling can be a useful tool for creating biomarker panels that can help guide therapeutic decision-making.
They provide a way to measure the activity of multiple kinases and substrate proteins in a single sample, which can be used to predict drug response, diagnose disease, and monitor treatment response.
Therapeutic Areas
Pepscope’s proprietary platform can be used in a broad spectrum of therapeutic areas. Contact us to learn more about how our technology can make an impact across various indications.
Start a conversation and start tuning your drug development.
