Helping you get the right tune in
Our services create a variety of opportunities for Protein Kinase Inhibitor (PKI) developers, but are especially valuable for people working on:
Combination Therapy
The resistance mechanism lies at the heart of developing combination therapies and by studying mechanism of action the complete picture is unraveled.
Drug Repurposing
Truly understanding the mechanism of action helps developers to bring new insights into abandoned or expiring drugs.
Biomarkers
Predicting drug response and reducing drug failure is pushing the need to identify new biomarkers.
Orchestrate and accelerate your PKI translation through in-depth kinome activity data.
Any researcher interested in multiplexity, endogenous activity, and pathway activity will benefit from Pepscope’s quantitative, targeted mass spectrometry technology. A solution to help you compose a melody that starts with the end in mind and provides integrated feedback.
Why do we need Kinome Activity Profiling for Protein Kinase Inhibitors (PKIs) development?
Kinome Activity Profiling is the next logical step in drug discovery.
Determining activity for a kinase in situ is complex, because kinase activity is tightly regulated by various modulating factors. Kinase activation is fine-tuned by post translation modifications (PTMs), of which phosphorylation is the most frequent regulatory PTM. By studying the human symphony of kinase activities we truly understand the drug’s mechanism of action (MOA), and aspects like signalling transduction and network activity.
